Nowadays, due to stricter pollution standards, more attention has been focused on pollutants emitted from cars. As a very dangerous pollutant, NOx has always triggered the sensitivity of the related organizations. In the process of developing and designing the engine, estimating the amount of this pollutant is of great importance to reduce future expenses. Calculating the amount of this pollutant has usually been complicated and prone to error. In the present paper, neural networks have been used to find the coefficients of correcting NOx calculation. The Zeldovich method calculated the value of NOx with 20% error. By applying the progressive neural network and correcting the equation coefficient, this value decreased. The related model has been vali- dated with other fuel equivalence ratios. The neural network model has fitted the experimental points with a convergence ratio of 0.99 and a squared error of 0.0019. Finally, the value of NOx anticipated by the neural network has been calculated and validated according to empirical data by applying maximum genetic algorithm. The maximum point for the fuel composed of 20% hydrogen and 80% methane occurred in the equivalence ratio of 0.9; and the maximum point for the fuel composed of 40% hydrogen occurred in equivalence ratio of 0.92. The consistency of the model findings with the empirical data shows the potential of the neural network in anticipating the amount of NOx.